Yeast and Cancer

The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression.

Diaz-Ruiz R, Rigoulet M, Devin A.

Source

Oxygen Sensing and Cancer Laboratory, Ludwig Institute for Cancer Research Ltd., Karolinska Institute, Nobels väg 3, SE-171 77 Stockholm, Sweden.

" From a metabolic point of view, the fermenting yeast Saccharomyces cerevisiae and tumor cells share several features. "

Yeast therapy for the treatment of breast cancer: a nude mice model study.

Ghoneum M, Wang L, Agrawal S, Gollapudi S.

Source

Drew University of Medicine and Science, Department of Otolaryngology, Los Angeles, CA, USA. mghoneum@ucla.edu

"S. cerevisiae is a promising anti-cancer agent that induces significant levels of apoptosis in malignant cells in vivo. However, yeast therapy for the treatment of breast cancer has yet to pass controlled clinical trials."

Yeasts encoding tumour antigens in cancer immunotherapy

Franzusoff A, Duke RC, King TH, Lu Y, Rodell TC

GlobeImmune, Inc., 12635 E. Montview Blvd, Aurora, CO 80010, USA.

"Recombinant yeast cells are capable of stimulating the immune system to produce highly specific and potent cellular responses against target protein antigens with little toxicity. Data from animal models suggest that Tarmogens (yeast-based immunotherapeutics) can elicit protective immunity against xenografted and chemically induced tumours."